Li-Fraumeni Syndrome in Breast Cancer: Development of Theranostic Probes on Variation of P53

Andy Yi, Jongwon Yun, Jian Lee and KyuBin Park
Additional contact information
Andy Yi: The Cambridge School of Weston, United States of America
Jongwon Yun: The Lawrenceville School, United States of America
Jian Lee: Seoul Academy, Republic of Korea
KyuBin Park: St. Johnsbury Academy Jeju, Republic of Korea

Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, 2024, vol. 10, 1-10

Abstract: Li-Fraumeni Syndrome (LFS) is a hereditary condition characterized by a high predisposition to various cancers due to mutations in the p53 protein. Effectively targeting and treating this syndrome requires early detection and personalized treatment according to one’s specific nucleotide sequence. With the use of various forms of theranostics, LFS can be treated, increasing life expectancy; however, there is no absolute cure that could immediately end this syndrome. This paper delves into three different theranostic approaches: Gendicine (rAd-p53), Phesgo, and gold nanoshell poly(D, L-lactic-co-glycolic acid) nanoparticles (PLGA NPs). While each approach has limitations, PLGA nanoparticles exhibit advantages that outweigh their drawbacks, making it an attractive solution. This proposal will describe improvements to PLGA nanoparticles, which are a promising area of research for the development of new LFS treatments.

Date: 2024
References: Add references at CitEc
Citations:

Downloads: (external link)
https://techniumscience.com/index.php/biochemmed/article/view/11797 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:tec:bioche:ojs:11797

DOI: 10.47577/biochemmed.v10i.11797

Access Statistics for this article

Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990 is currently edited by Anna Maria Golita

More articles in Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990 from Technium Science
Bibliographic data for series maintained by Anna Maria Golita ().