Insulin Resistance Indexes, Predictors of Diabetic Kidney Disease in Elderly Iraqis

Mayyada Bassim Rasul Aldbagh
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Mayyada Bassim Rasul Aldbagh: Department of Pathological Analyses, Faculty of Science, University of Kufa, Iraq

Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, 2025, vol. 12, 62-70

Abstract: This cross-sectional study aimed to evaluate the utility of three surrogate markers of insulin resistance, TyG, TG/HDL, and TyG-BMI in clinical practice by examining their association with diabetic kidney disease (DKD). Results: Of 476 patients with type 2 diabetes (T2DM), 42 (8.8%) had DKD. Patients with DKD showed significantly higher levels of BMI, fasting blood glucose, HbA1c, lipids, markers of renal dysfunction and three IR indices (TyG, TG/HDL and TyG-BMI) than those without DKD compared to those without DKD. Crosstabs/Risk analysis revealed that TyG index (OR = 1.39, 95% CI =1.218-1.587, p= 0.002), TG/HDL (OR =1.356, 1.189-1.545, p= 0.004), and TyG-BMI (OR =1.247, 1.073-1.450, p= 0.043). Based on the receiver operating characteristic curve, the areas under ROC with best cutoff values of TyG index, TG/HDL and TyG-BMI, were 0.762, 0.720 and 0.654, respectively and 9.5, 2.19 and 225, respectively. DKD patients >40 years had a significantly increased TyG index (p = 0.047) of 67.0% compared to patients

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:tec:bioche:ojs:12459

DOI: 10.47577/biochemmed.v12i.12459

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