 Rational Centre Selection for RCTs with a Parallel Economic Evaluation—the Next Step Towards Increased Generalisability?Adrian Gheorghe, Tracy Roberts, Thomas D. Pinkney, Dion G. Morton and Melanie Calvert Health Economics, 2015, vol. 24, issue 4, 498-504 Abstract: The paper discusses the impact of centre selection on the generalisability of randomised controlled trial (RCT)‐based economic evaluations and suggests a future research agenda. The first section briefly reviews the current methods for addressing generalisability. We argue that these methods make no verifiable assumptions about how representative the recruiting centres are to the population of centres in the jurisdiction. The second section uses data from a multicentre RCT to illustrate that cost‐effectiveness estimates can be influenced by the sample of recruiting centres. Finally, we propose two concepts that may advance generalisability research. First, we distinguish between the ‘research space’ and the ‘policy space’ and argue that policy makers are interested in the latter, while current methods describe the former. Second, we propose a centre‐specific generalisability index used at RCT design stage to address generalisability. We conclude that future research should focus on generalisability at RCT design stage rather than on post hoc analyses. Copyright © 2014 John Wiley & Sons, Ltd. Date: 2015 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:wly:hlthec:v:24:y:2015:i:4:p:498-504 Access Statistics for this article Health Economics is currently edited by Alan Maynard, John Hutton and Andrew Jones More articles in Health Economics from John Wiley & Sons, Ltd. |
Is your work missing from RePEc? Here is how to contribute.
Questions or problems? Check the EconPapers FAQ or send mail to .
EconPapers is hosted by the
School of Business at Örebro University.