Monoclonal B-Cell Lymphocytosis- Compromise of the Immune System?
Mike A Celis and
Wendy Nieto
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Mike A Celis: University of Santander, Faculty of Medical and Health Sciences, Masira Research Institute, Colombia
Wendy Nieto: International Hospital of Colombia, Department of Pathology, FCV Translational Biomedical Research Group, Colombia
Biomedical Journal of Scientific & Technical Research, 2023, vol. 48, issue 4, 40013-40014
Abstract:
Monoclonal B-Cell Lymphocytosis (MBL) is part of the mature B-cell neoplasms despite actually being a pre-neoplastic condition [1], this entity, largely unstudied, affects more than 5-10% of older adults age 40 and the incidence increases with aging [2,3], MBL is widely associated as one of the main risk factors for developing Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphocytic Lymphoma (SLL), since studies Prospective cohort studies verified, in effect, that CLL is always preceded by MBL, therefore, the greater the number of clonal B cells, the greater the risk of developing this type of cancer [4]. However, it is not ruled out that MBL is implicated in the lymphomagenesis of other pathologies such as follicular lymphoma and mantle cell lymphoma [5].
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Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:48:y:2023:i:4:p:40013-40014
DOI: 10.26717/BJSTR.2023.48.007698
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