Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change

A.P. Herrera, S.A. Snipes, D.W. King, I. Torres-Vigil, D.S. Goldberg and A.D. Wenberg

American Journal of Public Health, 2010, vol. 100, issue S1, S105-S112

Abstract: Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments' generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stakeholder network of researchers, community advocates, policymakers, and federal representatives, undertook, a critical analysis of older adults' structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes: (1) decision making with cognitively impaired patients; (2) pharmacokinetic differences and physiological age; (3) health literacy, communication, and aging; (4) geriatric training; (5) federal monitoring and accountability; (6) clinical trial costs; and (7) cumulative effects of aging and ethnicity. Chronic Disease Revention and Control Research.

Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:10.2105/ajph.2009.162982_5

DOI: 10.2105/AJPH.2009.162982

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