Directly observed antidepressant medication treatment and HIV outcomes among homeless and marginally housed HIV-positive adults: A randomized controlled trial

A.C. Tsai, D.H. Karasic, G.P. Hammer, E.D. Charlebois, K. Ragland, A.R. Moss, J.L. Sorensen, J.W. Dilley and D.R. Bangsberg

American Journal of Public Health, 2013, vol. 103, issue 2, 308-315

Abstract: Objectives. We assessed whether directly observed fluoxetine treatment reduced depression symptom severity and improved HIV outcomes among homeless and marginally housed HIV-positive adults in San Francisco, California, from 2002 to 2008. Methods. We conducted a nonblinded, randomized controlled trial of onceweekly fluoxetine, directly observed for 24 weeks, then self-administered for 12 weeks (n = 137 persons with major or minor depressive disorder or dysthymia). Hamilton Depression Rating Scale score was the primary outcome. Response was a 50% reduction from baseline and remission a score below 8. Secondary measures were Beck Depression Inventory-II (BDI-II) score, antiretroviral uptake, antiretroviral adherence (measured by unannounced pill count), and HIV-1 RNA viral suppression (

Keywords: antidepressant agent; antiretrovirus agent; fluoxetine, adult; article; CD4 lymphocyte count; CD4+ T lymphocyte; cohort analysis; controlled clinical trial; controlled study; depression; drug effect; female; follow up; homelessness; human; Human immunodeficiency virus; Human immunodeficiency virus infection; immunology; isolation and purification; male; middle aged; patient compliance; randomized controlled trial; severity of illness index; treatment outcome; United States; virology; virus load, Adult; Anti-Retroviral Agents; Antidepressive Agents, Second-Generation; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cohort Studies; Depressive Disorder; Female; Fluoxetine; Follow-Up Studies; HIV; HIV Infections; Homeless Persons; Humans; Male; Medication Adherence; Middle Aged; San Francisco; Severity of Illness Index; Treatment Outcome; Viral Load (search for similar items in EconPapers)
Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:10.2105/ajph.2011.300422_1

DOI: 10.2105/AJPH.2011.300422

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