A method for partitioning the attributable fraction of multiple time-dependent coexisting risk factors for an adverse health outcome

H. Lin, H.G. Allore, Gail McAvay, M.E. Tinetti, T.M. Gill, C.P. Gross and T.E. Murphy

American Journal of Public Health, 2013, vol. 103, issue 1, 177-182

Abstract: Objectives. We decomposed the total effect of coexisting diseases on a timed occurrence of an adverse outcome into additive effects from individual diseases. Methods. In a cohort of older adults enrolled in the Precipitating Events Project in New Haven County, Connecticut, we assessed a longitudinal extension of the average attributable fraction method (LE-AAF) to estimate the additive and order-free contributions of multiple diseases to the timed occurrence of a health outcome, with right censoring, which may be useful when relationships among diseases are complex. We partitioned the contribution to death into additive LEAAFs for multiple diseases. Results. The onset of heart failure and acute episodes of pneumonia during follow-up contributed the most to death, with the overall LE-AAFs equal to 13.0% and 12.1%, respectively. The contribution of preexisting diseases decreased over the years, with a trend of increasing contribution from new onset of diseases. Conclusions. LE-AAF can be useful for determining the additive and order-free contribution of individual time-varying diseases to a time-to-event outcome. Copyright © 2012 by the American Public Health Association®.

Keywords: aged; article; cause of death; cohort analysis; comorbidity; female; heart failure; human; longitudinal study; male; mortality; pneumonia; prognosis; risk factor; statistical model; time; United States, Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Comorbidity; Connecticut; Female; Heart Failure; Humans; Logistic Models; Longitudinal Studies; Male; Pneumonia; Prognosis; Risk Factors; Time Factors (search for similar items in EconPapers)
Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:10.2105/ajph.2011.300458_0

DOI: 10.2105/AJPH.2011.300458

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