25-hydroxyvitamin D in the range of 20 to 100 ng/mL and incidence of kidney stones

S. Nguyen, L. Baggerly, C. French, R.P. Heaney, E.D. Gorham and C.F. Garland

American Journal of Public Health, 2014, vol. 104, issue 9, 1783-1787

Abstract: Objectives. Increasing 25-hydroxyvitamin D serum levels can prevent a wide range of diseases. There is a concern about increasing kidney stone risk with vitamin D supplementation. We used Grassroots Health data to examine the relationship between vitamin D status and kidney stone incidence. Methods. The study included 2012 participants followed prospectively for a median of 19 months. Thirteen individuals self-reported kidney stones during the study period. Multivariate logistic regression was applied to assess the association between vitamin D status and kidney stones. Results. We found no statistically significant association between serum 25-hydroxyvitamin D and kidney stones (P = .42). Body mass index was significantly associated with kidney stone risk (odds ratio = 3.5; 95% confidence interval = 1.1, 11.3). Conclusions. We concluded that a serum 25-hydroxyvitamin D level of 20 to 100 nanograms per milliliter has no significant association with kidney stone incidence.

Keywords: 25 hydroxyvitamin D; 25-hydroxyvitamin D; drug derivative; vitamin D, adult; age; article; blood; body mass; diet supplementation; female; human; incidence; male; middle aged; nephrolithiasis; risk factor; sex difference, Adult; Age Factors; Body Mass Index; Dietary Supplements; Female; Humans; Incidence; Kidney Calculi; Male; Middle Aged; Risk Factors; Sex Factors; Vitamin D (search for similar items in EconPapers)
Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:10.2105/ajph.2013.301368_2

DOI: 10.2105/AJPH.2013.301368

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