Relations of depressive symptoms and antidepressant use to body mass index and selected biomarkers for diabetes and cardiovascular disease

Y. Ma, R. Balasubramanian, S.L. Pagoto, K.L. Schneider, J.R. Hébert, L.S. Phillips, J.S. Goveas, A.L. Culver, B.C. Olendzki, J. Beck, J.W. Smoller, D.M. Sepavich, J.K. Ockene, L. Uebelacker, M. Zorn and S. Liu

American Journal of Public Health, 2013, vol. 103, issue 8, e34-e43

Abstract: Objectives. We investigated whether depressive symptoms and antidepressant use are associated with biomarkers for glucose dysregulation and inflammation, body mass index (BMI), and waist circumference. Methods. Postmenopausal women were recruited into the Women's Health Initiative from 1993 to 1998, and data were collected at regular intervals through 2005. We used multiple linear regression models to examine whether depressive symptoms and antidepressant use are associated with BMI, waist circumference, and biomarkers. Results. Analysis of data from 71 809 women who completed all relevant baseline and year 3 assessments showed that both elevated depressive symptoms and antidepressant use were significantly associated with higher BMI and waist circumference. Among 1950 women, elevated depressive symptoms were significantly associated with increased insulin levels and measures of insulin resistance. Analyses of baseline data from 2242 women showed that both elevated depressive symptoms and antidepressant use were associated with higher C-reactive protein levels. Conclusions. Monitoring body habitus and other biomarkers among women with elevated depression symptoms or taking antidepressant medication may be prudent to prevent diabetes and cardiovascular disease. © 2013 American Journal of Public Health.

Keywords: antidepressant agent; biological marker; C reactive protein; insulin; interleukin 6; lipid; tumor necrosis factor alpha, aged; article; blood; body height; body mass; body weight; cardiovascular disease; depression; female; glucose blood level; human; inflammation; insulin resistance; middle aged; non insulin dependent diabetes mellitus; postmenopause; statistical model; waist circumference, Aged; Antidepressive Agents; Biological Markers; Blood Glucose; Body Height; Body Mass Index; Body Weight; C-Reactive Protein; Cardiovascular Diseases; Depression; Diabetes Mellitus, Type 2; Female; Humans; Inflammation; Insulin; Insulin Resistance; Interleukin-6; Linear Models; Lipids; Middle Aged; Postmenopause; Tumor Necrosis Factor-alpha; Waist Circumference (search for similar items in EconPapers)
Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:10.2105/ajph.2013.301394_7

DOI: 10.2105/AJPH.2013.301394

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