High mortality among non-HIV-infected people who inject drugs in Bangkok, Thailand, 2005-2012

S. Vanichseni, M. Martin, P. Suntharasamai, U. Sangkum, P.A. Mock, R.J. Gvetadze, M.E. Curlin, M. Leethochawalit, S. Chiamwongpaet, B. Chaipung, J.M. McNicholl, L.A. Paxton, S. Kittimunkong and K. Choopanya

American Journal of Public Health, 2015, vol. 105, issue 6, 1136-1141

Abstract: Objectives. We examined the causes of hospitalization and death of people who inject drugs participating in the Bangkok Tenofovir Study, an HIV preexposure prophylaxis trial. Methods. The Bangkok Tenofovir Study was a randomized, double-blind, placebo-controlled trial conducted during 2005 to 2012 among 2413 people who inject drugs. We reviewed medical records to define the causes of hospitalization and death, examined participant characteristics and risk behaviors to determine predictors of death, and compared the participant mortality rate with the rate of the general population of Bangkok, Thailand. Results. Participants were followed an average of 4 years; 107 died: 22 (20.6%) from overdose, 13 (12.2%) from traffic accidents, and 12 (11.2%) from sepsis. In multivariable analysis, older age (40-59 years; P = .001), injecting drugs (P = .03), and injecting midazolam (P

Keywords: adenine; anti human immunodeficiency virus agent; phosphonic acid derivative; tenofovir, adult; analogs and derivatives; cause of death; controlled study; double blind procedure; drug abuse; drug overdose; epidemiology; female; high risk behavior; HIV Infections; human; Kaplan Meier method; male; middle aged; mortality; pre-exposure prophylaxis; questionnaire; randomized controlled trial; substance abuse; Thailand; traffic accident, Accidents, Traffic; Adenine; Adult; Anti-HIV Agents; Cause of Death; Double-Blind Method; Drug Overdose; Female; HIV Infections; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Needle Sharing; Organophosphonates; Pre-Exposure Prophylaxis; Questionnaires; Risk-Taking; Substance Abuse, Intravenous; Thailand (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:10.2105/ajph.2014.302473_6

DOI: 10.2105/AJPH.2014.302473

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