Elimination of cotinine from body fluids: Disposition in smokers and nonsmokers

N.J. Haley, D.W. Sepkovic and D. Hoffmann

American Journal of Public Health, 1989, vol. 79, issue 8, 1046-1048

Abstract: We have evaluated differences in the elimination of cotinine, a major nicotine metabolite, in smokers who quit smoking and never-smokers who were exposed to environmental tobacco smoke (ETS) under controlled conditions. The mean biological half-life of cotinine in urine, collected from the nine smokers was 16.5 ± 1.2 h, in never-smokers exposed to ETS, 27.3 ± 1.9 h. Differences in the mode of uptake and absorption of nicotine and possible differences in nicotine metabolism may play roles in the clearance rate differences between smokers and nonsmokers.

Date: 1989
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:1989:79:8:1046-1048_7

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