 Urolithiasis in Tennessee: An occupational window into a regional problemM.J. Thun and S. Schober American Journal of Public Health, 1991, vol. 81, issue 5, 587-591 Abstract: Background: Urinary tract stones (stones) are believed to be unusually common in the southeastern United States but neither the incidence of nor the risk factors for stones are known. Methods: In three well-defined occupational populations in eastern Tennessee, we assessed the prevalence, incidence, and cumulative incidence of stones and measured biochemical risk factors for lithogenesis. Results: The age-adjusted prevalence of stones was 18.5 percent in Tennessee compared to 7.7 percent among White males in US NHANES (prevalence ratio 2.4, 95% CI 1.7, 3.3). The cumulative incidence (risk) was 27.8 percent by age 65, higher than in any other reported population. Risk factors were age, a family history, and urinary saturation with calcium-oxalate (COAX). Persons with a positive family history and the highest measured CAOX index had a predicted lifetime risk of 88.8 percent. Biochemical factors affecting lithogenesis were hypercalcuria, hyperoxaluria, and low urine volume. Conclusion: Future research should characterize the geographic boundaries of a southeastern ''stone-belt'' and explore genetic and dietary hypotheses that might explain it. Date: 1991 There are no downloads for this item, see the EconPapers FAQ for hints about obtaining it. Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:1991:81:5:587-591_0 Access Statistics for this article American Journal of Public Health is currently edited by Alfredo Morabia More articles in American Journal of Public Health from American Public Health Association |
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