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The progression of untreated HIV-1 infection prior to AIDS

D.R. Hoover, A. Saah, H. Bacellar, Richard Murphy (), B. Visscher, S. Metz, R. Anderson and R.A. Kaslow

American Journal of Public Health, 1992, vol. 82, issue 11, 1538-1541

Abstract: Using a case-control study of untreated men, we investigated the physical, mental, and economic effects of human immunodeficiency virus (HIV-1) infection prior to the diagnosis of acquired immunodeficiency syndrome (AIDS). Beginning 2 to 2.5 years prior to AIDS, case subjects reported more of 12 HIV-1 related symptoms and during the year prior to AIDS, at least 30.6 extra days of these symptoms than did control subjects. Within the 6 months preceding AIDS, case subjects' unemployment rose to 9% (P ≤ .05) and depression to 34.2% (P ≤ .001). At 6 to 12 months and within 6 months before AIDS, 17.1% and 31.5%, respectively, were anemic, while 37.7% and 64.7% had CD4+ counts less than 200 x 106/L. Diagnosing AIDS at CD4+ counts less than 200 x 106/L could significantly reduce pre-AIDS morbidity. Other implications of these findings are discussed.

Date: 1992
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Handle: RePEc:aph:ajpbhl:1992:82:11:1538-1541_6