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Risk factors for acute non-A, non-B hepatitis and their relationship to antibodies for hepatitis C virus: A case-control study

A. Mele, L. Sagliocca, G. Manzillo, F. Converti, P. Amoroso, M.A. Stazi, L. Ferrigno, M. Rapicetta, E. Franco, B. Adamo, F. Palumbo, C. Sbreglia, A. Pana and P. Pasquini

American Journal of Public Health, 1994, vol. 84, issue 10, 1640-1643

Abstract: A case-control study was carried out comparing 333 case subjects with non- A, non-B hepatitis and 1095 hospital control subjects. Of 333 case subjects, 197 (59%) were positive for hepatitis C antibody (anti-HCV). Excluding blood transfusion and intravenous drug use, surgical intervention and dental therapy were strongly associated with anti-HCV-positive cases: in particular, obstetric and gynecology surgical intervention was found to be strongly associated with HCV positivity (odds ratio [OR] = 32; 95% confidence interval [CI] = 7, 147). Raw shellfish consumption was a risk factor for anti-HCV- negative cases (OR = 2.2; 95% CI = 1.0, 5.1), thus suggesting an enterically transmitted virus in sporadic non-A, non-B hepatitis in Italy.

Date: 1994
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