A decision-analytic approach to postexposure rabies prophylaxis

S.B. Cantor, R.D. Clover and R.F. Thompson

American Journal of Public Health, 1994, vol. 84, issue 7, 1144-1148

Abstract: The risks and benefits of postexposure rabies prophylaxis were analyzed from clinical and economic perspectives. A decision-analytic model was constructed by using probability and outcome data from the literature and the state health department. Health outcomes were measured in quality-adjusted life years. In the base case (overweight adult male), treatment is optimal when the probability of animal rabidity is greater than 1 in 2000. Sensitivity analysis showed robustness in the treatment decision; however, the incremental cost-effectiveness ratio ($140 000/quality-adjusted life year) is sensitive to the rabidity probability. Treatment is optimal from the patient's perspective; however, it may not be cost-effective when the probability of rabidity is low.

Date: 1994
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:1994:84:7:1144-1148_0

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