The risk of Guillain-Barre syndrome after tetanus-toxoid-containing vaccines in adults and children in the United States

J. Tuttle, R.T. Chen, H. Rantala, J.D. Cherry, P.H. Rhodes and S. Hadler

American Journal of Public Health, 1997, vol. 87, issue 12, 2045-2048

Abstract: Objectives. This study examined whether there is a risk that tetanus- toxoid containing vaccines could cause Guillain-Barre syndrome and, if so, how large the risk is. Methods. This study was based on previous active surveillance epidemiological studies of Guillain-Barre syndrome and vaccination history. Results. A background rate of 0.3 cases of Guillain- Barre syndrome per million person-weeks has been estimated. By chance, 2.2 people with the syndrome would have received tetanus-toxoid-containing vaccine within the 6 weeks before onset, yet only 1 person had done so. Data on children show similar results. Conclusions. If an association exists, it must be extremely rare and not of public health significance.

Date: 1997
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:1997:87:12:2045-2048_0

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