Rapid Access to Synthesis of Bisindole Derivatives Using 2-Morpholino Ethanesulphonic Acid

Rajendra P. Pawar, Devidas S. Bhagat, Suresh U. Shisodia, Hanuman D. Bhosale, Sudam S. Pandule and Pravin S. Kendrekar
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Rajendra P. Pawar: Department of Chemistry, Deogiri College, Station Road, Aurangabad-431 005, MS, India
Devidas S. Bhagat: Department of Forensic Chemistry, Government Institute of Forensic Science, Aurangabad-431004 MS, India
Suresh U. Shisodia: Department of Chemistry, Deogiri College, Station Road, Aurangabad-431 005, MS, India
Hanuman D. Bhosale: Department of Chemistry, Deogiri College, Station Road, Aurangabad-431 005, MS, India
Sudam S. Pandule: Department of Chemistry, Nowrosjee Wadia College, Bund Garden Road, Pune 411001, MS, India
Pravin S. Kendrekar: Department of Chemistry and Directorate: Research Development, University of the Free State, Nelson Mandela Drive 205, Bloemfontein 9301, South Africa

Academic Journal of Chemistry, 2016, vol. 1, issue 1, 26-32

Abstract: The present work demonstrates easy and effective synthesis methodology for synthesis of bisindole derivatives in presence of protic organic acid 2-morpholino ethanesulphonic acid (MESA). 2-MESA is water soluble catalyst easy to extract and work-up for the synthesis of bisindole class of compounds. Catalyst is recovered and recycled by simple evaporation of water. Efficient aromatic electrophilic substitution of indoles (2 mmol) with aromatic aldehydes (1 mmol) equipped with various constituents were carried out employing a catalytic amount in ethanol to obtain bisindoles in good to excellent yields.

Keywords: 2-MESA (2-morpholino ethanesulphonic acid); Aldehyde; Bisindole; Green approach. (search for similar items in EconPapers)
Date: 2016
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