Synthesis, Characterization and DNA Binding Studies of Zn(II)/Cu(II) Complexes with 2,2`-Diphenyl Acetic Acid/2-(4-Hydroxyphenyl)Acetic Acid Ligand Precursors and Nitrogen Bases

Muhammad Naeem, Saqib Ali, Saira Shahzadi*, Kaleem Ullah, Shabbir Hussain, Sadaf Ramzan and Shagufta Kamal
Additional contact information
Muhammad Naeem: Department of Chemistry, University of Sargodha, Sargodha, Pakistan
Saqib Ali: Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
Saira Shahzadi*: Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
Kaleem Ullah: Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
Shabbir Hussain: Department of Chemistry, Lahore Garrison University, DHA Phase VI, Lahore, Pakistan
Sadaf Ramzan: Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
Shagufta Kamal: Department of Biochemistry, GC University, Faisalabad, Pakistan

Academic Journal of Chemistry, 2020, vol. 5, issue 1, 1-9

Abstract: The hydrated complexes 1, 3, 7 and 8 with the general formula (RCOO)2M.xH2O (where M = Zn & x = 6; M = Cu & x = 5,6) were synthesized by the reaction of sodium salt of 2,2`-diphenyl acetic acid or 2-(4-hydroxyphenyl)acetic acid (RCOONa) with Zn(NO3)2.6H2O or CuSO4.5H2O in an aqueous medium. The addition of methanolic solution of either bipyridine (bpy) or 1,10-phenanthroline (phen) to an aqueous suspension of 1, 3, 7 and 8 (produced in situ) result in the formation of mixed ligand products with the general formulae (RCOO)2M(bpy).xH2O (2, 4, 9 and 10) and (RCOO)2M(phen).xH2O (5 and 6). The complexes were characterized by microanalysis, FTIR and NMR (1H and 13C) spectroscopic techniques. The FTIR data suggested a bidentate coordination mode of the carboxylate ligand and complexes exhibited four/six-coordinated geometry in the solid state. The spectroscopic data also revealed the presence of coordinated water molecules in all complexes. 1H and 13C NMR data demonstrated the coordination between ligand and the metal in complex 1. The complexes were tested for their binding with salmon sperm DNA (SS-DNA). The DNA binding potential of the complexes owed to the presence of zinc metal and the nature of the incorporated ligand. The complexes showed a significant hypochromic effect and an intercalating mode of binding with SS-DNA. The complexes were screened against various bacterial and fungal strains to check their biological activity. All the complexes showed significant antibacterial activity but none of complex exhibit antifungal activity.

Keywords: Transition metal complexes; Zinc; Copper; IR; NMR; SS-DNA; Biological activity; Thermal analysis. (search for similar items in EconPapers)
Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.arpgweb.com/pdf-files/ajc5(1)1-9.pdf (application/pdf)
https://www.arpgweb.com/journal/20/archive/01-2020/1/5 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:arp:ajcarp:2020:p:1-9

DOI: 10.32861/ajc.51.1.9

Access Statistics for this article

Academic Journal of Chemistry is currently edited by Prof. Dr. Sadek khalifa Shakshooki

More articles in Academic Journal of Chemistry from Academic Research Publishing Group Rahim Yar Khan 64200, Punjab, Pakistan.
Bibliographic data for series maintained by Managing Editor ().