Adaptive two‐treatment two‐period crossover design for binary treatment responses

Uttam Bandyopadhyay, Atanu Biswas and Shirsendu Mukherjee

Statistica Neerlandica, 2007, vol. 61, issue 3, 329-344

Abstract: Adaptive designs are sometimes used in a phase III clinical trial with the aim, of allocating a larger number of patients to the better treatment. In the present paper, we use some adaptive designs in a two‐treatment two‐period crossover design where the treatment responses are binary. We use some simple designs to choose between the possible treatment combinations AA, AB, BA or BB. The goal is to use the better treatment a larger proportion of times. We calculate the allocation proportions to the possible treatment combinations and their standard deviations. We also study related inferential problems. Related asymptotics are derived. The proposed procedure is compared with some possible competitors. Finally, we use real data to illustrate the applicability of our proposed design.

Date: 2007
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://doi.org/10.1111/j.1467-9574.2007.00360.x

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bla:stanee:v:61:y:2007:i:3:p:329-344

Ordering information: This journal article can be ordered from
http://www.blackwell ... bs.asp?ref=0039-0402

Access Statistics for this article

Statistica Neerlandica is currently edited by Miroslav Ristic, Marijtje van Duijn and Nan van Geloven

More articles in Statistica Neerlandica from Netherlands Society for Statistics and Operations Research
Bibliographic data for series maintained by Wiley Content Delivery ().