Optimal designs for Cox regression

J. López‐Fidalgo, M. J. Rivas‐López and R. Del Campo

Statistica Neerlandica, 2009, vol. 63, issue 2, 135-148

Abstract: Optimal designs under a survival analysis framework have been rarely considered in the literature. In this paper, an optimal design theory is developed for the typical Cox regression problem. Failure time is modeled according to a probability distribution depending on some explanatory variables through a linear model. At the end of the study, some units will not have failed and thus their time records will be censored. In order to deal with this problem from an experimental design point of view it will be necessary to assume a probability distribution for the time an experimental unit enters the study. Then an optimal conditional design will be computed at the beginning of the study for any possible given time. Thus, every time a new unit enters the study, there is an experimental design to be determined. A particular and simple case is used throughout the paper in order to illustrate the procedure.

Date: 2009
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://doi.org/10.1111/j.1467-9574.2009.00415.x

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bla:stanee:v:63:y:2009:i:2:p:135-148

Ordering information: This journal article can be ordered from
http://www.blackwell ... bs.asp?ref=0039-0402

Access Statistics for this article

Statistica Neerlandica is currently edited by Miroslav Ristic, Marijtje van Duijn and Nan van Geloven

More articles in Statistica Neerlandica from Netherlands Society for Statistics and Operations Research
Bibliographic data for series maintained by Wiley Content Delivery ().