Analyzing Time-Course Microarray Data Using Functional Data Analysis - A Review

Coffey Norma and Hinde John

Statistical Applications in Genetics and Molecular Biology, 2011, vol. 10, issue 1, 1-32

Abstract: Gene expression over time can be viewed as a continuous process and therefore represented as a continuous curve or function. Functional data analysis (FDA) is a statistical methodology used to analyze functional data that has become increasingly popular in the analysis of time-course gene expression data. Several FDA techniques have been applied to gene expression profiles including functional regression analysis (to describe the relationship between expression profiles and other covariate(s)), functional discriminant analysis (to discriminate and classify groups of genes) and functional principal components analysis (for dimension reduction and clustering). This paper reviews the use of FDA and its associated methods to analyze time-course microarray gene expression data.

Keywords: functional data analysis; time-course microarray data; gene expression (search for similar items in EconPapers)
Date: 2011
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DOI: 10.2202/1544-6115.1671

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