A graph theoretical approach to data fusion

Žurauskienė Justina, Kirk Paul D.W. and Stumpf Michael P.H. ()
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Žurauskienė Justina: Theoretical Systems Biology Group, Centre for Bioinformatics, Imperial College London, South Kensington Campus, SW7 2AZ, London, UK
Kirk Paul D.W.: MRC Biostatistics Unit, Cambridge, CB2 0SR, Cambridge, UK
Stumpf Michael P.H.: Theoretical Systems Biology Group, Centre for Bioinformatics, Imperial College London, South Kensington Campus, SW7 2AZ, London, UK

Statistical Applications in Genetics and Molecular Biology, 2016, vol. 15, issue 2, 107-122

Abstract: The rapid development of high throughput experimental techniques has resulted in a growing diversity of genomic datasets being produced and requiring analysis. Therefore, it is increasingly being recognized that we can gain deeper understanding about underlying biology by combining the insights obtained from multiple, diverse datasets. Thus we propose a novel scalable computational approach to unsupervised data fusion. Our technique exploits network representations of the data to identify similarities among the datasets. We may work within the Bayesian formalism, using Bayesian nonparametric approaches to model each dataset; or (for fast, approximate, and massive scale data fusion) can naturally switch to more heuristic modeling techniques. An advantage of the proposed approach is that each dataset can initially be modeled independently (in parallel), before applying a fast post-processing step to perform data integration. This allows us to incorporate new experimental data in an online fashion, without having to rerun all of the analysis. We first demonstrate the applicability of our tool on artificial data, and then on examples from the literature, which include yeast cell cycle, breast cancer and sporadic inclusion body myositis datasets.

Keywords: clustering; data integration; functional genomics; graph-theoretic methods (search for similar items in EconPapers)
Date: 2016
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DOI: 10.1515/sagmb-2016-0016

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