Concerns About Unreliable Data from Spotted cDNA Microarrays Due to Cross-Hybridization and Sequence Errors

Handley Daniel, Serban Nicoleta, Peters David G and Glymour Clark
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Handley Daniel: University of Pittsburgh
Serban Nicoleta: Carnegie Mellon University
Peters David G: University of Pittsburgh
Glymour Clark: Carnegie Mellon University

Statistical Applications in Genetics and Molecular Biology, 2004, vol. 3, issue 1, 4

Abstract: We discuss our concerns regarding the reliability of data generated by spotted cDNA microarrays. Two types of error we highlight are cross-hybridization artifact due to sequence homologies and sequence errors in the cDNA used for spotting on microarrays. We feel that statisticians who analyze microarray data should be aware of these sources of unreliability intrinsic to cDNA microarray design and use.

Keywords: Cross-hybridization; Sequence Errors; cDNA microarray; Sources of Error (search for similar items in EconPapers)
Date: 2004
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DOI: 10.2202/1544-6115.1091

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