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Normalization of Dye Bias in Microarray Data Using the Mixture of Splines Model

Joo Yongsung, Casella George, Booth James, Lee Keunbaik and Enkemann Steven
Additional contact information
Joo Yongsung: University of Florida
Casella George: University of Florida
Booth James: Cornell University
Lee Keunbaik: University of Florida
Enkemann Steven: H. Lee Moffitt Cancer Center and Research Institution

Statistical Applications in Genetics and Molecular Biology, 2007, vol. 6, issue 1, 1-22

Abstract: This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.

Date: 2007
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DOI: 10.2202/1544-6115.1228

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