Case-Control Breast Cancer Study of MALDI-TOF Proteomic Mass Spectrometry Data on Serum Samples

J. van der Werff Martijn P., Mertens Bart, E de Noo Mirre, Bladergroen Marco R, Dalebout Hans C, Tollenaar Rob A. E. M. and Deelder Andre M
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J. van der Werff Martijn P.: Leiden University Medical Center
Mertens Bart: Leiden University Medical Center
E de Noo Mirre: Leiden University Medical Center
Bladergroen Marco R: Leiden University Medical Center
Dalebout Hans C: Leiden University Medical Center
Tollenaar Rob A. E. M.: Leiden University Medical Center
Deelder Andre M: Leiden University Medical Center

Statistical Applications in Genetics and Molecular Biology, 2008, vol. 7, issue 2, 14

Abstract: We introduce mass spectrometry proteomic research for diagnosis from a clinical perspective, with special reference to early-stage breast cancer detection. The nature of SELDI and MALDI mass spectrometric measurement is discussed. We explain how the mass spectral data arising from this technology may be viewed as a new data type. Some of the properties of the data are discussed and we show how such spectra may be interpreted. Sample preprocessing for mass spectrometry is introduced and a literature review of research in clinical proteomics is presented. Finally, we provide a detailed description of the study design on the breast cancer case-control study which is investigated in this special issue.

Keywords: case-control; breast cancer; proteomic; spectrometry; MALDI-TOF (search for similar items in EconPapers)
Date: 2008
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DOI: 10.2202/1544-6115.1352

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