Diffusional release of a dispersed solute from a cylindrical polymeric matrix into an infinite external volume

Zeynab Mousavi Khamene and Mohammad J. Abdekhodaie

Applied Mathematics and Computation, 2015, vol. 259, issue C, 676-685

Abstract: Numerical and analytical exact solutions of diffusional release from a cylindrical polymeric matrix into an infinite medium have been developed in which the initial solute loading (A) is greater than solubility limit (Cs). Also, the effects of boundary layers on the drug release rate have been studied. The numerical solution is valid for any initial drug loading whereas analytical solution can be used for high values of drug loading. Comparisons have been made between numerical and analytical exact solutions in upper and lower bounds (A/Cs≫1 and A/Cs→1) and previously presented approximate solution. The presented results validate the proposed numerical solution.

Keywords: Cylindrical polymeric matrix; Drug release; Dispersed solute; Exact solution; Controlled release; Moving boundary problem (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:eee:apmaco:v:259:y:2015:i:c:p:676-685

DOI: 10.1016/j.amc.2015.02.063

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