Lempel-Ziv complexity of the pNNx statistics – an application to neonatal stress

Matej Šapina, Chandan Kumar Karmakar, Karolina Kramarić, Marcin Kośmider, Matthieu Garcin, Dario Brdarić, Krešimir Milas and John Yearwood

Chaos, Solitons & Fractals, 2021, vol. 146, issue C

Abstract: Among the existing measures of heart rate variability (HRV), the pNN50 statistics is one of the most commonly reported. However, it is only a single member of a much larger family of HRV measures – the pNNx statistics. In this research pNNx was further extended, combining it with the Lempel-Ziv complexity (LZ76) in a controlled neonatal stress framework. Two different types of stress stimuli on forty healthy newborns – a routine heel stick blood sampling, and a dull heel pressure stimulation – were considered by recording time intervals between heartbeats. Instead of relying on a single value, the entire spectrum from pNN1 to pNN100 was calculated, along with LZ76 derived from binarized sequences for each NN. The results of this study show a downward shift of the pNNx curves when newborns are stressed, with reduced LZ76 complexity when stressed. When ROC curves were utilized for the pNNx statistics and LZ76, however, the highest AUC values were observed when both measures were combined, with the highest AUC values of 0.88 (0.80-0.94) and 0.85 (0.74-0.91) for discriminating resting states from stress phases. Combining the widely used pNNx statistics with LZ76 extends the existing HRV toolbox, and shows a promising application in recognizing acute neonatal stress.

Keywords: Heart rate variability; Lempel-Ziv complexity; Newborns; Stress; Cardiac inter-beat interval; Pain (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0960077921000564
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:146:y:2021:i:c:s0960077921000564

DOI: 10.1016/j.chaos.2021.110703

Access Statistics for this article

Chaos, Solitons & Fractals is currently edited by Stefano Boccaletti and Stelios Bekiros

More articles in Chaos, Solitons & Fractals from Elsevier
Bibliographic data for series maintained by Thayer, Thomas R. ().