Stochastic analysis of a complex gene-expression model

Aimin Chen, Tianhai Tian, Yiren Chen and Tianshou Zhou

Chaos, Solitons & Fractals, 2022, vol. 160, issue C

Abstract: Gene expression has been extensively studied in terms of Markov processes, but its stochastic mechanisms including how noisy sources contribute to expression levels still remain not fully understood. To reveal more reasonable mechanisms, it is needed to consider more molecular events occurring in gene-expression processes. Here we introduce and analyze a general gene-expression model described by a chemical master equation. This model simultaneously considers negative feedback, bursting and promoter cyclic structure, thus extending most gene-expression models in the existing literature. First, we uncover the hierarchy of this complex transcription process by deriving the probability-generating function expressed by an Euler integral formula. Second, we further derive analytical mRNA distribution, which includes previous results as its special cases and provides new insights into the roles of chromatin remodeling and feedback in fine-tuning the mRNA noise. Third, we show that the multi-OFF mechanism always reduces the mRNA noise, but the effect of feedback on the mRNA noise is complex, depending on the detail of the multi-OFF mechanism. The overall analysis provides a paradigm for investigation into expression noise and gene-expression mechanisms in more complex cases.

Keywords: Gene model; Gene-expression noise; Feedback; Chromatin remodeling; Chemical master equation (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:160:y:2022:i:c:s0960077922004714

DOI: 10.1016/j.chaos.2022.112261

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