 A delayed fractional-order tumor virotherapy model: Stability and Hopf bifurcationSaida Amine, Youssra Hajri and Karam Allali Chaos, Solitons & Fractals, 2022, vol. 161, issue C Abstract: A fractional-order tumor virotherapy model with two time delays is presented and analyzed in this paper. The existence, positivity and bounbdedness of solutions under positive initial conditions will be proved. The basic reproduction number R0 and the immune response reproduction number R1 are given. The virus-free equilibrium E0 and the therapy partial success equilibrium E∗ are presented depending on the value of R0 and R1. Sufficient conditions to ensure the local stability of both the virus-free equilibrium and the therapy partial success equilibrium according to different values of two time delays are established. By considering the time delay as a bifurcation parameter, it was appeared that the model undergoes a Hopf bifurcation when the delay passes through a critical value. Finally, numerical simulations were carried out to support the theoretical results and to show the effect of both the fractional-order derivative and the time delays. Keywords: Cancer treatment; Virotherapy; Two delays; Immune response; Local stability; Hopf bifurcation (search for similar items in EconPapers) Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:161:y:2022:i:c:s0960077922006063 DOI: 10.1016/j.chaos.2022.112396 Access Statistics for this article Chaos, Solitons & Fractals is currently edited by Stefano Boccaletti and Stelios Bekiros More articles in Chaos, Solitons & Fractals from Elsevier |
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