Structure and dynamics of human complication-disease network

Xiong-Fei Jiang, Long Xiong, Ling Bai, Jie Lin, Jing-Feng Zhang, Kun Yan, Jia-Zhen Zhu, Bo Zheng and Jian-Jun Zheng

Chaos, Solitons & Fractals, 2022, vol. 164, issue C

Abstract: A complication is an unanticipated disease arisen following, induced by a disease, a treatment or a procedure. We compile a human disease-complication network from the medical data and investigate the characteristics of the network. It is observed that the modules of the network are dominated by the classes of diseases. The relations between modules are unveiled in detail. Three nontrivial motifs are identified from the network. We further simulate the dynamics of motifs with the Boolean dynamic model. Each motif represents a specific dynamic behavior, which is potentially functional in the disease system, such as generating temporal progressions and governing the responses to fluctuating external stimuli.

Keywords: Medicine; Complex networks; Complication disease; Motif; Boolean dynamic model (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:164:y:2022:i:c:s0960077922008141

DOI: 10.1016/j.chaos.2022.112633

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