Obesity and Alzheimer’s: An attempt to decipher the role of obesity in blood–brain barrier degradation

Ani Jain and Parimita Roy

Chaos, Solitons & Fractals, 2023, vol. 166, issue C

Abstract: The effects of obesity on memory and cognitive function have been reported, which could further lead to Alzheimer’s disease (AD). Observational studies have found both a negative and a positive association between body shape and AD. For this purpose, we designed a diffusive obesity–Alzheimer’s model consisting of fat cells, glucose, insulin, beta cells, cytokines, microglia, Aβ plaques, and neurofibrillary tangles. We have shown the developed model’s global existence, non-negativity, and long-term behavior. Additionally, equilibrium points for the ODE are analyzed for existence and stability. We adopted the Partial Rank Correlation Coefficient (PRCC) to conduct a global sensitivity analysis to estimate the most sensitive parameters responsible for Aβ and τ plaque progression. We provided a complete numerical analysis based on our deterministic and diffusive models. A patchy pattern is typically formed in mathematical simulations of spatially explicit systems, reflecting complicated spatiotemporal dynamics. This work suggests that insulin resistance and pro-inflammatory microglia may be responsible for obesity-associated cognitive decline.

Keywords: Alzheimer; Obesity; Microglia; Amyloid-β plaque; Neurofibrillary tangles; Diet control (search for similar items in EconPapers)
Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0960077922010815
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:166:y:2023:i:c:s0960077922010815

DOI: 10.1016/j.chaos.2022.112902

Access Statistics for this article

Chaos, Solitons & Fractals is currently edited by Stefano Boccaletti and Stelios Bekiros

More articles in Chaos, Solitons & Fractals from Elsevier
Bibliographic data for series maintained by Thayer, Thomas R. ().