Synchrony dynamics and synaptic plasticity in E-I networks modulated by prolonged astrocytic BDNF

Jiajia Li, Duoyu Feng, Xuan Zhang and Ying Wu

Chaos, Solitons & Fractals, 2025, vol. 201, issue P1

Abstract: Long-timescale cortical activation has demonstrated significant effect on the neuronal plasticity through both non-invasive visual and auditory stimulations. Experimental studies demonstrated that astrocytes could participate in this process by releasing BDNF. Although neuronal BDNF dynamics in different time-scales have been investigated, how astrocytic BDNF affects the neural plasticity remains obscure. This study innovatively develops a large-scale excitatory-inhibitory neuronal network model integrating synaptic plasticity from long-timescale astrocytic BDNF dynamics. Computational simulations reveal that accumulated astrocytic BDNF over minutes triggers neural synchrony transitions, which shows crucial for the implementation of long-timescale cortical activation. Further analysis of a 2D large - scale cortical network shows the long-timescale cortical activation restorative effects are mainly governed by inter-cluster connection strength and density. Specifically, sites with stronger directional global connectivity are more likely to induce global cortical activation from a localized stimulus. This suggests they are promising targets for achieving long-timescale whole-brain activation.

Keywords: Synchronous dynamics; Synaptic plasticity; Long- timescale effect; Astrocyte (search for similar items in EconPapers)
Date: 2025
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0960077925012755
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:201:y:2025:i:p1:s0960077925012755

DOI: 10.1016/j.chaos.2025.117262

Access Statistics for this article

Chaos, Solitons & Fractals is currently edited by Stefano Boccaletti and Stelios Bekiros

More articles in Chaos, Solitons & Fractals from Elsevier
Bibliographic data for series maintained by Thayer, Thomas R. ().