Fractal discrimination of random fractal aggregates and its application in biomarker analysis for blood coagulation

M.R. Brown, D.J. Curtis, P. Rees, H.D. Summers, K. Hawkins, P.A. Evans and P.R. Williams

Chaos, Solitons & Fractals, 2012, vol. 45, issue 8, 1025-1032

Abstract: A recent rheological study has established that the fractal dimension, df, of an incipient clot, formed at the Gel Point (sol–gel transition) of coagulating blood is a significant new biomarker of haemostasis. In whole healthy blood, incipient clots show a clearly defined value of df=1.7 within a narrow range, which represents a new ‘healthy index’ for normal clotting. The addition of unfractionated heparin significantly prolongs the onset of clot formation with a corresponding reduction of df as a function of heparin dose. However, as clots mature they exhibit (i) an expected increase in df and (ii) a significant increase to spread of these values, i.e. df’s in the range 2.0–2.5, limiting the use of df as a discriminant of clot microstructure.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:45:y:2012:i:8:p:1025-1032

DOI: 10.1016/j.chaos.2012.04.004

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