Coupling switches and oscillators as a means to shape cellular signals in biomolecular systems

Peipei Zhou, Shuiming Cai, Zengrong Liu, Luonan Chen and Ruiqi Wang

Chaos, Solitons & Fractals, 2013, vol. 50, issue C, 115-126

Abstract: To understand how a complex biomolecular network functions, a decomposition or a reconstruction process of the network is often needed so as to provide new insights into the regulatory mechanisms underlying various dynamical behaviors and also to gain qualitative knowledge of the network. Unfortunately, it seems that there are still no general rules on how to decompose a complex network into simple modules. An alternative resolution is to decompose a complex network into small modules or subsystems with specified functions such as switches and oscillators and then integrate them by analyzing the interactions between them. The main idea of this approach can be illustrated by considering a bidirectionally coupled network in this paper, i.e., coupled Toggle switch and Repressilator, and analyzing the occurrence of various dynamics, although the theoretical principle may hold for a general class of networks. We show that various biomolecular signals can be shaped by regulating the coupling between the subsystems. The approach presented here can be expected to simplify and analyze even more complex biological networks.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:50:y:2013:i:c:p:115-126

DOI: 10.1016/j.chaos.2012.11.011

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