Dynamic transition on the seizure-like neuronal activity by astrocytic calcium channel block

Jiajia Li, Rong Wang, Mengmeng Du, Jun Tang and Ying Wu

Chaos, Solitons & Fractals, 2016, vol. 91, issue C, 702-708

Abstract: The involvement of astrocytes in neuronal firing dynamics is becoming increasingly evident. In this study, we used a classical hippocampal tripartite synapse model consisting of soma-dendrite coupled neuron models and a Hodgkin–Huxley-like astrocyte model, to investigate the seizure-like firing in the somatic neuron induced by the over-expressed neuronal N-methyl-d-aspartate (NMDA) receptors. Based on this model, we further investigated the effect of the astrocytic channel block on the neuronal firing through a bifurcation analysis. Results show that blocking inositol-1,4,5-triphosphate(IP3)-dependent calcium channel in astrocytes efficiently suppresses the astrocytic calcium oscillation, which in turn suppresses the seizure-like firing in the neuron.

Keywords: Neuronal activity; Astrocyte; Seizures; Channel block (search for similar items in EconPapers)
Date: 2016
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Citations: View citations in EconPapers (5)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:91:y:2016:i:c:p:702-708

DOI: 10.1016/j.chaos.2016.08.009

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