Toxicokinetic–toxicodynamic modelling in an individual based context—Consequences of parameter variability

Roman Ashauer

Ecological Modelling, 2010, vol. 221, issue 9, 1325-1328

Abstract: Toxicokinetic–toxicodynamic (TKTD) models simulate the time-course of toxicant concentration in the organism and toxicity at the level of the organism. A link between TKTD models that simulate survival and individual based models for populations (IBMs) is proposed which allows TKTD parameters to vary between individuals. The TKTD-IBM predicts different survival in response to toxicants when TKTD parameters vary amongst individuals compared to the survival predicted with fixed TKTD parameters. The model with fixed parameters represents the concept of stochastic death whereas the model with variable parameters behaves, at least partly, according to the individual tolerance distribution concept. The whole set of TKTD parameters of an individual can be interpreted as constituting “individual tolerance”.

Keywords: Mechanistic effect models; Survival; Ecotoxicology; Individual tolerance; Hazard models; Individual based model; Heterogeneity; Pulsed exposure (search for similar items in EconPapers)
Date: 2010
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Citations: View citations in EconPapers (2)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:ecomod:v:221:y:2010:i:9:p:1325-1328

DOI: 10.1016/j.ecolmodel.2010.01.015

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