Modelling of paralytic shellfish toxin biotransformations in the course of Crassostrea gigas detoxification kinetics

Marielle Guéguen, Régis Baron, Michèle Bardouil, Philippe Truquet, Hansy Haberkorn, Patrick Lassus, Laurent Barillé and Zouher Amzil

Ecological Modelling, 2011, vol. 222, issue 18, 3394-3402

Abstract: The aim of this study was to evaluate the importance of biotransformation of paralytic shellfish toxins during the detoxification process in contaminated oysters. Mathematical models based upon the detoxification patterns of digestive gland and other tissues were developed. It was demonstrated that biotransformations do not seem to play an important role in digestive gland or other tissue detoxification kinetics with our data set. Moreover, different toxin transfers from digestive gland toward other tissues were investigated. No significant transfer was highlighted in our data set. These first conclusions were drawn after comparing the results obtained from 13 biotransformations and identifiable transfer scenarios. Finally, to determine a more robust model, all 12 states corresponding to toxic compounds and tissues were aggregated into a single state model. The best adjustment was obtained with a simple one-compartment model based on total flesh toxicity with elimination rate expressed by a function depending on initial concentrations of GTX3 and GTX2 (i.e. the two major toxic compounds found in contaminated oysters).

Keywords: Detoxification kinetics modelling; Biotransformation of saxitoxin analogues; Oyster (search for similar items in EconPapers)
Date: 2011
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0304380011003772
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:ecomod:v:222:y:2011:i:18:p:3394-3402

DOI: 10.1016/j.ecolmodel.2011.07.007

Access Statistics for this article

Ecological Modelling is currently edited by Brian D. Fath

More articles in Ecological Modelling from Elsevier
Bibliographic data for series maintained by Catherine Liu ().