Using the standard DEB animal model for toxicokinetic-toxicodynamic analysis

Tjalling Jager, Benoit Goussen and André Gergs

Ecological Modelling, 2023, vol. 475, issue C

Abstract: Toxicokinetic-toxicodynamic (TKTD) models are essential tools to close the gap between laboratory toxicity tests and impacts on individuals under field conditions. For sub-lethal effects on life-history traits, dynamic energy budget (DEB) theory provides a solid basis for TKTD modelling. Various DEB-based TKTD models have been presented, ranging from complex and comprehensive to simple and reduced. Here we present a complete and up-to-date model formulation at the complex end of the range. The basic part of the model, governing the life cycle of the species without toxicant stress, is formed by the standard DEB animal model. This part can directly use the species-specific model parameters from the add-my-pet (AmP) library. Additionally, we cover one extension of the standard model with metabolic acceleration for some time after birth (the abj-model). The basic DEB model is augmented by a TKTD model that explicitly considers damage as driving force for the toxic effects, and which considers various feedbacks from life-history traits to damage dynamics (e.g., dilution by growth). Several choices are needed in this linkage, which are made explicit. A Matlab-based toolbox is presented to support the model analyses, which is illustrated with a case study for the springtail Folsomia candida exposed to chlorpyrifos in food.

Keywords: Dynamic energy budget; Toxicokinetic-toxicodynamic modelling; DEBtox; Ecotoxicity; Standard DEB animal (search for similar items in EconPapers)
Date: 2023
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:ecomod:v:475:y:2023:i:c:s030438002200285x

DOI: 10.1016/j.ecolmodel.2022.110187

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