 Recent advances on the Discretizable Molecular Distance Geometry ProblemCarlile Lavor, Leo Liberti, Nelson Maculan and Antonio Mucherino European Journal of Operational Research, 2012, vol. 219, issue 3, 698-706 Abstract: The Molecular Distance Geometry Problem (MDGP) consists in finding an embedding in R3 of a nonnegatively weighted simple undirected graph with the property that the Euclidean distances between embedded adjacent vertices must be the same as the corresponding edge weights. The Discretizable Molecular Distance Geometry Problem (DMDGP) is a particular subset of the MDGP which can be solved using a discrete search occurring in continuous space; its main application is to find three-dimensional arrangements of proteins using Nuclear Magnetic Resonance (NMR) data. The model provided by the DMDGP, however, is too abstract to be directly applicable in proteomics. In the last five years our efforts have been directed towards adapting the DMDGP to be an ever closer model of the actual difficulties posed by the problem of determining protein structures from NMR data. This survey lists recent developments on DMDGP related research. Keywords: Graph theory; Bioinformatics; Protein conformation; Branch-and-prune (search for similar items in EconPapers) Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:eee:ejores:v:219:y:2012:i:3:p:698-706 DOI: 10.1016/j.ejor.2011.11.007 Access Statistics for this article European Journal of Operational Research is currently edited by Roman Slowinski, Jesus Artalejo, Jean-Charles. Billaut, Robert Dyson and Lorenzo Peccati More articles in European Journal of Operational Research from Elsevier |
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