Data-driven dynamic treatment planning for chronic diseases

Christof Naumzik, Stefan Feuerriegel and Anne Molgaard Nielsen

European Journal of Operational Research, 2023, vol. 305, issue 2, 853-867

Abstract: In order to deliver effective care, health management must consider the distinctive trajectories of chronic diseases. These diseases recurrently undergo acute, unstable, and stable phases, each of which requires a different treatment regimen. However, the correct identification of trajectory phases, and thus treatment regimens, is challenging. In this paper, we propose a data-driven, dynamic approach for identifying trajectory phases of chronic diseases and thus suggesting treatment regimens. Specifically, we develop a novel variable-duration copula hidden Markov model (VDC-HMMX). In our VDC-HMMX, the trajectory is modeled as a series of latent states with acute, stable, and unstable phases, which are eventually recovered. We demonstrate the effectiveness of our VDC-HMMX model on the basis of a longitudinal study with 928 patients suffering from low back pain. A myopic classifier identifies correct treatment regimens with a balanced accuracy of slightly above 70%. In comparison, our VDC-HMMX model is correct with a balanced accuracy of 83.65%. This thus highlights the value of longitudinal monitoring for chronic disease management.

Keywords: Machine learning; Treatment regimen; Copula; Bayesian modeling; Hidden Markov model (search for similar items in EconPapers)
Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S037722172200491X
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:ejores:v:305:y:2023:i:2:p:853-867

DOI: 10.1016/j.ejor.2022.06.016

Access Statistics for this article

European Journal of Operational Research is currently edited by Roman Slowinski, Jesus Artalejo, Jean-Charles. Billaut, Robert Dyson and Lorenzo Peccati

More articles in European Journal of Operational Research from Elsevier
Bibliographic data for series maintained by Catherine Liu ().