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A Monte Carlo estimation of the mean residence time in cells surrounded by thin layers

Antoine Lejay

Mathematics and Computers in Simulation (MATCOM), 2018, vol. 143, issue C, 65-77

Abstract: We present a new Monte Carlo method to estimate the mean-residence time of a diffusive particle in a domain surrounded by a thin layer of low diffusivity. Through a homogenization technique, the layer is identified with a membrane. The simulations use a stochastic process called the snapping out Brownian motion the density of which matches suitable transmission conditions at the membrane. We provide a benchmark test which is a simplified form of a real-life problem coming from brain imaging techniques. We also provide a new algorithm to adaptively estimate the exponential rate of the tail of the distribution function of the probability to be in the domain using Monte Carlo simulations.

Keywords: Semi-permeable membrane; Snapping out Brownian motion; Thin layer problem; Mean-residence time; First eigenvalue estimation (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:143:y:2018:i:c:p:65-77

DOI: 10.1016/j.matcom.2017.05.008

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