 Bifurcations and multistability in a virotherapy model with two time delaysQinrui Dai, Mengjie Rong and Ren Zhang Mathematics and Computers in Simulation (MATCOM), 2022, vol. 198, issue C, 289-311 Abstract: In this paper, we establish a delayed virotherapy model including infected tumor cells, uninfected tumor cells and free virus. In this model, both infected and uninfected tumor cells have special growth patterns, and there are at most two positive equilibria. We mainly analyze the stability and Hopf bifurcation of the model under different time delays. For the model without delay, we study the Hopf and Bogdanov–Takens bifurcations. For the delayed model, by center manifold theorem and normal form theory of functional differential equation, we study the direction of Hopf bifurcation and stability of the bifurcated periodic solution. Moreover, we prove the existence of Zero-Hopf bifurcation. Finally, some numerical simulations show the results of our theoretical calculations, and the dynamic behaviors near Zero-Hopf and Bogdanov–Takens point of the system are also observed in the simulations, such as bistability, periodic coexistence and chaotic behavior. Keywords: Virotherapy; Double time delays; Bogdanov–Takens bifurcation; Zero-Hopf bifurcation (search for similar items in EconPapers) Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:198:y:2022:i:c:p:289-311 DOI: 10.1016/j.matcom.2022.02.028 Access Statistics for this article Mathematics and Computers in Simulation (MATCOM) is currently edited by Robert Beauwens More articles in Mathematics and Computers in Simulation (MATCOM) from Elsevier |
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