Construction of more reliable complex metabolic models without repeated solution of their constituent differential equations

David Garfinkel, Michael C. Kohn, Murray J. Achs, John Phifer and Gruia-Catalin Roman

Mathematics and Computers in Simulation (MATCOM), 1978, vol. 20, issue 1, 18-27

Abstract: A method is described for constructing metabolic models composed of many nonlinear stiff differential equations. The system being modeled is divided into subunits (where such division is impractical, forcing functions are used), and algebraic relationships for their behavior at an instant in time are derived. Most of the usual searches for correct model structure and parameter sets are then done with the set of these algebraic relationships at different time points, relatively few expensive differential equation solutions being required. The software used, the application to several models of cardiac metabolism, and the significance of models of this type are discussed.

Date: 1978
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/0378475478900502
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:20:y:1978:i:1:p:18-27

DOI: 10.1016/0378-4754(78)90050-2

Access Statistics for this article

Mathematics and Computers in Simulation (MATCOM) is currently edited by Robert Beauwens

More articles in Mathematics and Computers in Simulation (MATCOM) from Elsevier
Bibliographic data for series maintained by Catherine Liu ().