Modeling and multi-objective optimal state-dependent control of a continuous double-bioreactor in series fermentation

Juan Wang, Feiyan Zhao, Jichao Wang and An Li

Mathematics and Computers in Simulation (MATCOM), 2025, vol. 231, issue C, 331-351

Abstract: This paper models a continuous double-bioreactor in series fermentation of glycerol to 1,3-propanediol by a nonlinear dynamic system and formulates its process control by a multi-objective optimal control problem formulating the dilution rates as varying-coefficient state-dependent controls. Control parameterization and time scale transformation are firstly applied to transform the proposed optimal control problem into a large-scale parameter optimization problem, which is then solved by a novel numerical algorithm based on an improved dynamic neighborhood learning strategy and a classified pairwise competition mechanism. Numerical results suggest that the proposed algorithm has good diversity of solutions and convergence to the Pareto optimal front for complex multi-objective problems. Numerical comparisons indicate that the proposed control has the characters of shorter computation time, higher calculation accuracy, and poorer stability when compared to two closed-loop controls, and is better in system stability and improving mean productivity compared to two other open-loop controls. Simulation curves also show the potential application of double-bioreactor in series fermentation.

Keywords: Process control; State-dependent control; Large-scale optimization; Classified competition; Continuous fermentation (search for similar items in EconPapers)
Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378475424004804
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:231:y:2025:i:c:p:331-351

DOI: 10.1016/j.matcom.2024.12.008

Access Statistics for this article

Mathematics and Computers in Simulation (MATCOM) is currently edited by Robert Beauwens

More articles in Mathematics and Computers in Simulation (MATCOM) from Elsevier
Bibliographic data for series maintained by Catherine Liu ().