Modeling the effects of obesity on a tumor-immune model with combined therapy

Wenjie Qin, Yi Zhao and Jin Yang

Mathematics and Computers in Simulation (MATCOM), 2025, vol. 233, issue C, 276-295

Abstract: This paper examines and analyzes a mathematical model that describes the interactions between tumors, immune cells, healthy cells, and stored fat in the body. The model incorporates integrated therapy as a key component of the analysis. We first prove that the system exists with a global positive solution which is unique. Subsequently, we derive threshold conditions determining the elimination and persistence of tumor cells, immune cells and fat cells, employing Stochastic Differential Equations theory. Additionally, we investigate the system’s smooth distribution and its ergodic properties. The results indicate that therapies marked by pronounced stochastic disturbances, elevated medication dosages or shortened treatment cycles can effectively hinder tumor growth and simultaneously promote weight loss. A low-calorie diet leads to a decrease in body weight and a reduction in tumor cells, underscoring the potential benefits of weight management as a supplementary strategy to chemotherapy. Notably, combination therapy reduces the detrimental effects of chemotherapy on healthy cells.

Keywords: Tumour-immune system; Obesity; Pulsed therapy; Extinction and persistence; Stationary distribution (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:233:y:2025:i:c:p:276-295

DOI: 10.1016/j.matcom.2025.02.004

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