A modeling investigation of the disease severity driven by COVID-19-induced diabetic patients

Ashabul Hoque, Razia Sultana, Hamidul Islam and Abdul Malek

Mathematics and Computers in Simulation (MATCOM), 2025, vol. 237, issue C, 213-230

Abstract: In this study, we introduce a novel SEICHR compartmental model to explore the transmission dynamics of COVID-19 among diabetic and non-diabetic patients, with a particular focus on the impact of COVID-19-induced diabetes on disease progression. The well-posedness of the model and the stability of the equilibrium points are confirmed through rigorous mathematical analysis. Mathematical results are validated using numerical simulations. Sensitivity and bifurcation analyses are conducted to determine the most sensitive parameters in the proposed model. The sensitivity of the model parameters is examined using the partial rank correlation coefficients (PRCC) analysis. The results show that the disease progression rate is higher among COVID-19 infected diabetic patients than non-diabetic patients. Numerical simulations further indicate that the forward bifurcation region expands progressively with increasing rates of disease development. The role of COVID-19-induced diabetic patients in exacerbating disease severity is examined through both constant and progressive delays in hospital isolation. Notably, the progressive waiting time exerts a significantly greater impact on transmission dynamics than the constant waiting time.

Keywords: COVID-19; Diabetic patients; Bifurcation analysis; PRCC analysis; Stability analysis (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:237:y:2025:i:c:p:213-230

DOI: 10.1016/j.matcom.2025.04.011

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