High-resolution models of motion of macromolecules in cell membranes

Karin Leiderman and Stanly Steinberg

Mathematics and Computers in Simulation (MATCOM), 2008, vol. 77, issue 4, 383-399

Abstract: The path of a macromolecule on a cell membrane is modeled by a sum of independent identically distributed random variables. Random variables with simple discrete distribution functions capture some important aspects of the jump or hop diffusion reported from single particle tracking experiments that measure the motion of single molecules on a cell membrane. The detail provided by the distribution function for the random variables is critical for accurate simulations of the motion and interactions of macromolecules on the cell membrane. Additionally, the probability distribution for the random variables is easily estimated from single-particle tracking data. The diffusion constant is given by the second moment of the probability distribution, which agrees with the diffusion constant estimated from the mean-square displacement, and thus represents far less information than the distribution function.

Keywords: Cell membrane; Macromolecules; Anomolous diffusion (search for similar items in EconPapers)
Date: 2008
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378475407001620
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:77:y:2008:i:4:p:383-399

DOI: 10.1016/j.matcom.2007.03.008

Access Statistics for this article

Mathematics and Computers in Simulation (MATCOM) is currently edited by Robert Beauwens

More articles in Mathematics and Computers in Simulation (MATCOM) from Elsevier
Bibliographic data for series maintained by Catherine Liu ().