Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment

František Maršík, Václav Klika and Hynek Chlup

Mathematics and Computers in Simulation (MATCOM), 2010, vol. 80, issue 6, 1278-1288

Abstract: Remodelling is a dynamic process occurring during growth and it includes sensing of environmental changes, tissue resorbance, i.e. the removal of existing old bone, and formation of new tissue. The biomechanical remodelling process is relatively well formulated for bones and can be divided into three stages: (1) bone resorption based on the osteoclast activity, (2) bone deposition based on the osteoblast activity and (3) bone growth control established on RANK/RANKL/OPG pathway—RANKL/OPG balance. The main driving force of remodelling process is a dynamic loading (cyclic compression and expansion, e.g. walking or running), which strongly influences the rate of chemical reactions. The evolution from the homogeneous density distribution to the corticalis and cancellous bone formation is shown. An inevitable influence of a dynamic mechanical loading and osteoprotegerin (OPG) concentration is demonstrated. Deformations were calculated by commercial code ANSYS. The clinical experience indicates that the dynamic loading (above the threshold level 1500–2500microstains/s), especially walking with a characteristic time approximately 1s, influences the whole process of bone remodelling after a time period of approximately 3 months. The numerical simulation shows that the concentration of the new bone and the bone elastic constants substantially depend on history and intensity of the loading, drug delivery and nutrition.

Keywords: Bone remodelling; Chemical kinetics; Biochemical model; Numerical simulation (search for similar items in EconPapers)
Date: 2010
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378475409000664
Full text for ScienceDirect subscribers only

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:80:y:2010:i:6:p:1278-1288

DOI: 10.1016/j.matcom.2009.02.014

Access Statistics for this article

Mathematics and Computers in Simulation (MATCOM) is currently edited by Robert Beauwens

More articles in Mathematics and Computers in Simulation (MATCOM) from Elsevier
Bibliographic data for series maintained by Catherine Liu ().