Protein stability and foldability–designability complementarity

Michele Vendruscolo

Physica A: Statistical Mechanics and its Applications, 1998, vol. 249, issue 1, 576-580

Abstract: We address the question of how evolution has possibly enhanced protein functionality by a complementary selection of sequences and structures. We show how the requirement of good functionality implies a two-way link between thermodynamic stability and resistance against mutations. The existence of families of structures emerges as a possible consequence of these evolution criteria.

Keywords: Protein folding; Mutations; Thermodynamic stability (search for similar items in EconPapers)
Date: 1998
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:249:y:1998:i:1:p:576-580

DOI: 10.1016/S0378-4371(97)00518-9

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