The dimension dependence of gel electrophoresis

Jan A. Leegwater

Physica A: Statistical Mechanics and its Applications, 1998, vol. 251, issue 1, 202-210

Abstract: We study the significance of self-avoidance on the dynamics of a reptating polymer in a field. We show that in two dimensions the drift velocity decreases with field above a certain field strength due to self-trapping of the polymer. This phenomenon does not occur in more than two dimensions. We conclude that there is a crucial difference between electrophoresis in two and electrophoresis in more than two dimensions and that electrophoresis in a plane has the potential for a much better size-selectivity than gel electrophoresis in three dimensions. Moreover, we establish a scaling law for the drift velocity of a two-dimensional polymer, and show that the scaling variable is N2.5±0.03ε.

Keywords: Reptation; Scaling; Electrophoresis; Self-trapping (search for similar items in EconPapers)
Date: 1998
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:251:y:1998:i:1:p:202-210

DOI: 10.1016/S0378-4371(97)00604-3

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